Manual Organic Synthesis: The Disconnection Approach

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Covering both synthesis and strategy, the chapters on synthesis detail the synthesis of given types of molecules, alternating with strategy chapters which place the methods just learned in a wider context. The synthesis chapters cover many ways of making each type of molecule starting with simple aromatic and aliphatic compounds; the strategy chapters cover questions of selectivity, protection, and stereochemistry. By working through this book, students will develop their skills in analyzing synthetic challenges, and build a toolkit of strategies for planning new syntheses.

Workbook for Organic Synthesis: The Disconnection Approach, 2nd Edition :: Book :: ChemistryViews

Preis inkl. MwSt, zzgl. One approach to organic synthesis is retrosynthetic analysis.


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With this approach chemists start with the structures of their target molecules and progressively cut bonds to create simpler molecules. Reversing this process gives a synthetic route to the target molecule from simpler starting materials. This "disconnection" approach to synthesis is now a fundamental part of every organic synthesis course.

Workbook for Organic Synthesis: The Disconnection Approach, 2nd Edition This workbook provides a comprehensive graded set of problems to illustrate and develop the themes of each of the chapters in the textbook Organic Synthesis: The Disconnection Approach, 2nd Edition. Each problem is followed by a fully explained solution and discussion. The examples extend the student's experience of the types of molecules being synthesised by organic chemists, and the strategies they employ to control their syntheses.

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By working through these examples students will develop their skills in analysing synthetic challenges, and build a toolkit of strategies for planning new syntheses. Examples are drawn from pharmaceuticals, agrochemicals, natural products, pheromones, perfumery and flavouring compounds, dyestuffs, monomers, and intermediates used in more advanced synthetic work.

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Reasons for wishing to synthesise each compound are given. Organic Synthesis : The Disconnection Approach. Stuart Warren , Paul Wyatt. One approach to organic synthesis is retrosynthetic analysis.

Retrosynthetic analysis

With this approach a chemist will start with the structure of their target molecule and progressively cut bonds to create simpler molecules. Reversing this process gives a synthetic route to the target molecule from simpler starting materials.

Chem 125. Advanced Organic Chemistry. 22. Retrosynthetic Analysis. Diels-Alder; Robinson Annulation.

The Order of Events. Reversal of Polarity. Protecting Groups.


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Choosing a Disconnection. Cyclisation Reactions.

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SixMembered Rings. Strategy of Ring Synthesis. Aromatic Heterocycles CarbonHeteroatom Disconnections.